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We strive to set the standard for quality, safety and value in the discovery, development and manufacture of health care products, including innovative medicines and vaccines. SAFETY INFORMATION FROM THE U. Febrile neutropenia has been reported in 1. IBRANCE across PALOMA-2 and PALOMA-3. Advise male patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of sensitive CYP3A substrates with a narrow therapeutic index may need to be reduced as IBRANCE may increase their exposure.

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